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Journal: bioRxiv
Article Title: Targeting Microbial Bile Salt Hydrolase Reprograms Bile Acid Metabolism and Ameliorates Metabolic Dysfunction–Associated Steatohepatitis in Mice
doi: 10.64898/2026.05.12.724693
Figure Lengend Snippet: a , Experimental design. Male C57BL/6 Foz/Foz mice were fed chow diet (CD) or western diet (WD). GR-7 was administered either as early intervention (EI) starting at week 3 of WD feeding or as late intervention (LI) starting at week 12, at low (0.034%) or high (0.1%) dietary doses. Group sizes are indicated. b , Longitudinal food intake during early intervention. c , Cumulative food intake during early intervention. d , Longitudinal food intake during late intervention. e , Cumulative food intake during late intervention. f , Longitudinal body weight gain during early intervention. g , Longitudinal body weight gain during late intervention. h , Cumulative body weight gain during early intervention. i , Cumulative body weight gain during late intervention. j , Short-term dietary GR-7 intervention schematic in WD-fed wild-type mice. k , Daily food intake following short-term dietary GR-7 treatment. l , Body weight gain during short-term dietary GR-7 treatment. m , Oral gavage intervention schematic in WD-fed wild-type mice receiving PBS or GR-7. n , Daily food intake following oral gavage of PBS or GR-7. o , Body weight gain following oral gavage of PBS or GR-7. Data are shown as mean ± SD. Each symbol represents one mouse/one cage. Statistical significance was determined by one-way ANOVA with Bonferroni’s multiple-comparisons test. For comparisons between two groups, Mann–Whitney U test was used. * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001.
Article Snippet:
Techniques: Western Blot, MANN-WHITNEY
Journal: bioRxiv
Article Title: Erythroferrone Modulates Osteoblast-Osteoclast Crosstalk During Bone Remodeling
doi: 10.64898/2026.05.05.722997
Figure Lengend Snippet: ( A ) Bone mineral density (BMD) assessed using DXA scan in the whole body, femur, tibia, and lumbar vertebrae (L4-L6) of 14-week-old Erfe +/+ (wild type), Erfe −/− , Erfe fl/fl and Col2.3 -Cre; Erfe fl/fl mice ( N = 10). ( B-D ) Three-dimensional images of micro-CT analyses in the distal femur, lumbar vertebrae, and femoral midshaft. ( E-F ) Quantitative micro-CT analyses of trabecular structure; BMD, bone volume fraction (BV/TV), trabecular number (Tb.N), trabecular thickness (Tb.Th), trabecular separation (Tb.Sp) at the distal femur and lumbar vertebrae ( N = 9). ( G ) Quantitative micro-CT analyses of cortical structure; BMD and cortical thickness (Ct.Th) at the midshaft of femoral bone ( N = 9). Data are presented as mean ± SEM. ** P < 0.01 using two-tail Student t test.
Article Snippet:
Techniques: Micro-CT